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LBs,the pathologic hallmark of PD (see Figures 2.11 and 2.12),not only occur in the SN in PD but also are found in thedorsal motor nucleus of the vagus, substantia innomi-nata, other brainstem nuclei, the intermedolateral cell col-umns of the spinal cord, and sympathetic ganglia (Braaket al., 2003). 12.8) and is characterized by an underlying layer ofdense material. Functional impairment characterized by decreased range of shoulder motionis observed in less than 20% of the patients. The synaptonemalcomplex is often compared to railroad tracks with an ad-ditional third rail positioned in the middle between twoothers. The majorrole played by the central motor output to theoral cavity and pharyngeal muscles that modifyPcrit is emphasized by the fact that OSA occursonly in sleep, predominantly in REM sleep inchildren (Marcus 2000)
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